The Indirayani Express was introduced on 27 April 1988 by Indira Gandhi and is one of six dedicated Intercity Chair Car trains between Mumbai CSMT and Pune Junction.

In the return service as 22106, it halts at Lonavala, Karjat, Kalyan, Thane, Dadar and Mumbai CSMT.

Since March 2022, as the route is electrified, it is currently hauled by WAP-7 pure AC locomotive of the Kalyan shed.

From November 2009 till March 2022, it was hauled by WDM-3A or WDP 4, to save time in locomotive change, due to the rake sharing with Pune Solapur Intercity Express, as the route after Daund Junction was not electrified.

During the COVID-19 pandemic, all passenger trains of Indian Railways were suspended for operating from 24 March 2020 due to lockdown.