[1] It was founded in 1973 and is headquartered in Hsinchu City, Taiwan, with branch offices in the U.S., Europe,[2] and Japan.

Its open lab and incubator have fostered emerging industries and startups including UMC and TSMC.

In 2002, ITRI partnered with Apex Medical and started the development of respiratory therapy product series.

In 2019, ITRI banned all smartphones and computers made by China's Huawei from their internal network for security reasons.

[8] As of 2019, self-driving cars designed by ITRI had accumulated more than 2,000 km of testing in the Changhua Coastal Industrial Park.