The series follows the adventures of Cole MacGrath, Delsin Rowe and Abigail "Fetch" Walker, super-powered "Conduits" who must decide their own destinies of becoming either good or evil.

Their powers come from a gauge which depletes whenever they uses various attacks, and refills when they absorb electricity, smoke, neon, video or concrete from nearby sources.

The comics take place in between the events of the first and the second game, showing how Cole escapes from Empire City to New Marais.

The graphic novel had four chapters, each focusing on Cole MacGrath and John White trying to survive in the quarantined Empire City immediately after the blast.

In 2009, Sony had chosen screenwriter Sheldon Turner to adapt Infamous into a feature film in a seven figure deal.

Brothers Ari and Avi Arad were hired to produce, and Sony executives Matt Tolmach and Jonathan Kadin as handlers for the studio.