The narration is primarily through the perspectives of Perry Dawsey, an ex-football player with an anger problem, and Margaret Montoya, an epidemiologist with the CDC who is investigating a strange disease that turns seemingly normal people into murderers.

[4] The San Francisco Chronicle panned the book, stating that the book's intensity "might work in a series of cliff-hanging audio episodes, but as a novel to be read in a few sittings, Infected can't rise above its overheated prose and rote characterizations.

"[5] The Guardian also reviewed Infected, criticizing the book's "portentous cliff-hangers and one-dimensional characters".

[6] The Sacramento News's "Bibliolatry" praised Infected, calling it "imaginative, gross, frightening, suspenseful, funny, thought-provoking and sick in the "omigawd-I-wanna-barf" way".

[11] In 2010, work began on a graphic novel adaptation of Sigler's Infected, with the series to be published by IDW in the summer of 2012.