The superior labial branches descend deep to the levator labii superioris to supply the skin of the anterior cheek and upper lip.

[2] The infraorbital nerve provides sensory innervation to the skin of the lower eyelid,[2] the side of the nose,[2] the moveable part of nasal septum,[citation needed] the anterior cheek,[citation needed] and part of the upper lip.

[citation needed] The infraorbital nerve is often blocked with local anesthetic to induce analgesia.

[4] The infraorbital nerve can be implicated in trigeminal neuralgia, where patients have severe orofacial pain.

[5] A fracture of the floor of the orbit can injure the infraorbital nerve resulting in anesthesia in its sensory distribution.