The remainder was hotel rooms and was frequented by well-known guests such as Judy Garland, Gypsy Rose Lee, Roy Rogers, Dean Martin, Bob Hope, Jerry Lewis and Irv Kupcinet[4] The top floor, known as the Skyline Terrace Penthouse housed the Chicago Press Club from 1960 to 1978.

Shell Hospitality Group reopened the hotel in February 1982 as part of the Best Western chain.

In November 2006, the Chartres Lodging Group umbrella of hotels purchased the Inn of Chicago from Best Western for $40 million.

[7] The restoration resulted in 359 guest rooms, six suites, and 5,800 square feet (540 m2) of meeting space.

IOC Hotel, LLC, a joint venture between The Chartres Lodging Group of San Francisco and Longwing Real Estate Ventures, LLC, a member of the Dubai Investment Group purchased the Inn of Chicago.