The club won the North-West Charity Cup that season, beating Derry Celtic Wanderers 4–1 in the final, making them the first Junior team ever to win the trophy.

In the 1910–11 season, although the team lost Billy Gillespie to Leeds City, they managed to reach the semi-final of the Irish Junior Cup, in which they were defeated 2–1 by Broadway United at the Brandywell.

The 1911–12 season saw the club reach the final of the Irish Junior Cup, narrowly losing out on winning the trophy after a 2–1 defeat by Brantwood at Grosvenor Park, Belfast.

That season saw four players reach 100 appearances for the club, these were Graeme Philson, Adrian Creane, Ryan Coyle and John McGarvey.

This was accompanied by great success in the Craig Memorial Cup, lifting the trophy after beating Tobermore United in a penalty shoot-out, when the match ended in a stalemate 1–1 result at Fortwilliam Park.

The club lifted the Irish Intermediate Cup for the first ever time after defeating Ards Rangers 1–0 in the final with a late winner from Darren McFadden.

Once again the club were promoted to the top tier after being crowned champions of NIFL Championship 1 on the final day of the season, with a 1–1 draw against Harland & Wolff Welders for Bangor meaning the 2–0 win in the North-West derby at home to Limavady United was enough to see the club finish top of the pile for the second time.

A 2014–2015 NIFL Premiership season in which the club were relegated once more after a 12th (bottom) placed finish, also saw a North-West Senior Cup triumph, beating Moyola Park 3–1 in the final at the Riverside Stadium in October 2014.

Manager Kevin Deery handed in his resignation following the season end, on 20 May 2017, following discussions with chairman Bill Anderson and was replaced by his assistant, and former club captain, Paddy McLaughlin, on 24 May 2017.

The 2018–19 season saw the club finish eighth place in the NIFL Premiership, as well as the departure of manager Paddy McLaughlin, (in February 2019), who left to take the Cliftonville job.

Following the resignation of John Quigg on 3 August 2019 after just two matches in charge; Sean Connor was appointed as first team manager a month later, on 14 September, with the club yet to win a game in the 2019–20 season.

Prior to the pandemic, Institute had reached the NIFL League Cup semi-final for the first time in the history of the club, where a 2–0 defeat to Crusaders was the result.

Deery's first season on his return (2023-24), saw a second-placed finish for Institute and a 2-1 aggregate loss to Ballymena United in what was a third NIFL Premiership promotion/relegation play-off with the club, for the manager.

The club's former home was Riverside Stadium located in Drumahoe, Derry and had a total capacity of 3,110 people with 1,540 seated.

In 1995 it was decided that the club would make plans to develop the ground to meet IFA regulation standard, to gain entry to the Irish League.

The building of the stand was the main part of a £956,000 project to both increase the capacity (for safety) and also improve the overall facilities at the ground.

The major funder of the project was Sport NI with the remainder of the funding coming from the IFA and Derry City Council.

In 2008, the club improved disabled access at the ground and provided a public address system, additional toilets and emergency lighting.

In December 2015, club chairman Bill Anderson spoke in local newspaper Londonderry Sentinel, about plans for a 4G playing surface within the ground, and asked for the backing of the club's supporters and local councillors with the matter of acquiring the appropriate funding required from Northern Irish football's governing bodies in order for the plans to proceed.

Severe flooding through the North-West of Northern Ireland on the evening of 22 August 2017 devastated the club when the ground was destroyed by water reaching as high as 7-foot inside changing rooms and with 5-foot of sediment piled on top of what was left of the playing surface (which would later develop Japanese Knotweed).

Following promotion to the NIFL Premiership, the club entered a ground sharing agreement with Derry City and the Derry City and Strabane District Council for the use of Brandywell Stadium the 2018–19 season as a temporary fix, for a ground capable of meeting the requirements set by the NIFL for a club competing in the top tier.

This agreement was continued into the 2019–20 season and a 5-year plan was put forward by the club, with an aim to relocate to a new purpose-built stadium in the Clooney Park West site, of Derry's Waterside area.

In 2019, a 5-year plan was put forward by the club, with the aim to relocate to a new purpose-built stadium in the Clooney Park West site, of Derry's Waterside area.

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