[6] Over the years, it acquired several other MUMPS implementations: DTM from Data Tree (1993); DSM from Digital (1995);[7] and MSM from Micronetics (1998); making InterSystems the dominant M technology vendor.

[14] Epic Systems, a privately held health records vendor, is the company’s largest customer and has been using InterSystems technology for more than 40 years.

3M, BNY Mellon, Canon, Franklin Templeton, HSBC, MSC Mediterranean Shipping Company, Olympus, Ricoh, SPAR, and TD Ameritrade also use InterSystems software.

[30] In 2010, CEO Terry Ragon led a coalition in Cambridge called Save Our Skyline to protest a city zoning change that would have allowed more signs on top of commercial buildings, partly in response to Microsoft's desire to put a sign on top of their shared building.

[31] Both disputes were eventually settled, and Microsoft and InterSystems agreed to both put low signs only in front of the building at street level.