[9] The secondary division opened officially on January 13, 2012 by the Right Honourable Mrs Ank Bijleveld, the Queen's Commissioner for the province of Overijssel.

The secondary division of ISTwente locates inside the Zuid campus of Het Stedelijk Lyceum.

A canteen is in service for ISTwente and a carpark belonging to the Zuid campus is located in front of the school.

The primary division of ISTwente is located separately in its own independent building in Johannes ter Horststraat 30, 7513 ZH Enschede.

ISTwente is known to offer a flexible programme in which students who are more capable are allowed to take more classes than expected and are not restricted to age limits for exams and graduation.