Other software projects no longer in active development include OpenReg and ISC AFTR (an implementation of an IPv4/IPv6 transition protocol based on Dual-Stack Lite).

[3][4] Over the years a number of additional software systems were operated under ISC (for example: INN and Lynx) to better support the Internet's infrastructure.

ISC also expanded their operational activities to include Internet hosting facilities for other open-source projects such as NetBSD, XFree86, kernel.org, secondary name-service (SNS) for more than 50 top-level domains, and a DNS OARC (Operations, Analysis and Research Center) for monitoring and reporting of the Internet's DNS.

ISC is actively involved in the community design process; it authors and participates in the development of the IETF standards, including the production of managed open-source software used as a reference implementation of the DNS.

[8] In early 2020, ISC closed its headquarters in Redwood City, California and moved its operations to Newmarket, New Hampshire.

[16] The earliest published reports, dated 1993, were performed by Network Wizards owner Mark K. Lottor.