The transition between the Interstate and the state-numbered highway occurs just east of the McCloy Street overpass south of the Carytown district of Richmond.

[2][3] I-195 continues northeast as a six-lane freeway; its median is occupied by CSX Transportation's two-track North End Subdivision, which is also used by Amtrak.

The southbound I-195 has an exit ramp to Hamilton Street, which parallels the highway to the west, to serve SR 147 and Grove Avenue.

North of Monument Avenue, from which the southbound direction receives a ramp, I-195 has a multipart interchange with Broad Street, which carries US 33 and US 250.

North of the S-curved viaduct, I-195 has a three-quarter diamond interchange with the western end of Laburnum Avenue, which provides access to SR 197.