It crosses into the state from Florida at the St. Marys River near Kingsland and travels to the north past the cities of Brunswick and Savannah to the South Carolina state line at the Savannah River near Port Wentworth.

The route also passes through the cities of Richmond Hill, Darien, and Woodbine.

From the Florida state line to the west of Savannah, I-95 travels along the US Route 17 (US 17) corridor, passing near or through marshlands, and is close to the Atlantic coastline.

The Interstate continues generally north-northeast, bypassing the smaller communities of Woodbine and Waverly en route to Brunswick, where it intersects US 17, US 25, and US 341.

The freeway leaves Brunswick, bypassing the cities of Darien and Midway, before reaching the southern suburbs of Savannah.

The route first encounters US 17 again, this time in Richmond Hill, before intersecting SR 204, a busy freeway and southern bypass into Savannah.

The route then reenters the city limits of Savannah and then intersects SR 17.

I-95 leaves Georgia via twin bridges over the Savannah River and heads north into South Carolina.

Other rest areas, weigh stations, and visitor centers operate independently with no access to any other facilities or destinations.

[2][3] In 1970, the highway was under construction from the Florida state line to just southeast of Woodbine.

[10][11] In 1971, it was under construction from the Florida state line to northeast of White Oak and also between the US 17/SR 25 interchanges north of South Newport and in Richmond Hill.

[17][18] In 1998, the Georgia State Senate passed a resolution to designate the portion of I-95 between the Ogeechee River (Bryan–Chatham county line) north to the Savannah River in the Savannah metropolitan area as the Tom Coleman Highway, in honor of Tom Coleman, a Democrat who served as state senator from 1981 to 1995.

[19] Until 2000, the state of Georgia used the sequential interchange numbering system on all of its Interstate Highways.