It continues east across the Harlem River on the Alexander Hamilton Bridge and onto the Cross Bronx Expressway.

North of the interchange with Pelham Parkway, it then continues northeast via the New England Thruway (which is part of the New York State Thruway system) out of New York City into Westchester County and to the Connecticut state line, where I-95 continues on the Connecticut Turnpike.

At its western end, the Trans-Manhattan Expressway is part of I-95, US 1, and US 9 at the eastern approach to the George Washington Bridge.

Roughly midway across Manhattan, US 9 leaves the freeway to follow Broadway northward toward the Bronx and Westchester County.

The expressway was announced in 1957 and built in conjunction with the addition of the lower level of the George Washington Bridge.

The City of New York approved the creation of the highway in June 1957 as part of a joint effort with the Port Authority that also called for the creation of the lower deck on the George Washington Bridge and construction of the George Washington Bridge Bus Terminal above the cut for the Expressway.

[14] Local traffic reporters frequently refer to congestion "under the Apartments" during morning and evening rush hours.

[6] At East 176th Street, the Cross Bronx Expressway turns southeast, entering exit 4A eastbound, which marks the northern terminus of NY 895 (Sheridan Boulevard).

[6] After a curve from the parkway, the Cross Bronx Expressway begins paralleling East 177th Street[16] and enters exit 5A, which connects to White Plains Road in Parkchester.

After Castle Hill Avenue, the route enters exit 6A, which reaches the Hutchinson River Parkway at the Bruckner Interchange.

Now known as the New England Thruway, I-95 leaves Pelham Bay Park and enters exit 9, a junction with the Hutchinson River Parkway.

In the middle of the interchange with the Hutchinson River, exit 10 forks to the left, reaching Gun Hill Road.

[6] Crossing through the northern reaches of Pelham Bay Park, I-95 turns more northeast and enters Westchester County.

North of exit 16, the New England Thruway enters its lone toll gantry along the alignment, serving the northbound direction only.

[6] Turning northeast again, I-95 enters exit 18B, a partial cloverleaf interchange with Mamaroneck Avenue before crossing into the town of Harrison.

I-95 was assigned on August 14, 1957, as part of the establishment of the Interstate Highway System[2] and has always run along its current path in New York.

The expressway was announced in 1957 and built in conjunction with the addition of the lower level of the George Washington Bridge.

The City of New York approved the creation of the highway in June 1957 as part of a joint effort with the PANYNJ that also called for the creation of the lower deck on the George Washington Bridge and construction of the George Washington Bridge Bus Station above the cut for the expressway.

[24] The expressway, the main New York approach to the George Washington Bridge, is only 0.8 miles (1.3 km) long.

[14] Local traffic reporters frequently refer to congestion "under the Apartments" during morning and evening rush hours.

[30] Prior to the change, the Cross Bronx/Bruckner Expressway and New England Thruway sections had different exit numbering systems.

During the late 1970s, and 1980s, in various stages, the mid-mast cuptlight-luminaire, a variant of high-mast lighting, lamps were installed onto the entire New England Thruway.