After the service area, the turnpike continues due north to Wichita and intersects I-135 (exit 42).

I-35 passes through Wichita's suburbs and, in the process, intersects US-54/US-400 (East Kellogg Avenue, exit 53A).

Thereafter, the route intersects US-77 (North Main Street, exit 76) and various state highways near El Dorado.

After El Dorado, the highway enters the Flint Hills region of Kansas.

I-35 passes through a toll plaza to continue on its own alignment running eastward through east-central Kansas.

[1] The Kansas Department of Transportation (KDOT) worked with the Burns & McDonnell engineering company to design a new interchange at Homestead Lane (exit 205) in Johnson County as a diverging diamond.