Four business routes of Interstate 49 (I-49) exist, all of them within the state of Missouri.

Most of the road is a previous alignment of US 71, which was realigned west of Neosho as a freeway and was eventually upgraded to I-49.

is an alternate alignment of I-49/US 71 which begins at a junction of I-49/US 71 and Route 175 at Tipton Ford, Missouri, midway between Joplin and Neosho.

is a relatively long one and begins its existence as a nonfreeway divided highway at I-49/US 71, heading north until it meets I-44.

At one point, Route 175 had been labeled US 71 Bus., and the road continued south as US 71 Bus.

It begins at I-49/US 71 in the east-central part of the city and ends at the same highway on the northside of town.

This is one of the shortest alignments of the many US 71 business routes throughout western Missouri.

It begins at I-49/US 71 near Passaic and ends at the same highway south of Butler.