Route 59 is a highway in southwest Missouri running from the Arkansas state line north to I-44/I-49 at Fidelity.

When US 71 was moved east of Joplin in the late 1990s, Alternate US 71 was deleted, and Route 59 was extended north to replace that highway.

Route 59 is a two-lane highway for its entire length except for a short section in southern Neosho where it forms a concurrency with Business I-49.

The road runs under some of the bluffs along the Elk River (with signs warning of low clearance for trucks).

Finally, the highway becomes a freeway and ends at I-44/I-49/US 71 at a cloverleaf interchange in Fidelity where the road continues north as I-49/US 71 heading towards Kansas City.