Interstate 526 (I-526) is a 19.56-mile (31.48 km) auxiliary route of I-26, providing a partial beltway around Charleston, South Carolina, in the United States.

The four-lane freeway heads north past the Citadel Mall and meets SC 461 at a partial cloverleaf interchange.

The freeway has diamond interchanges with Leeds Avenue and SC 642 (Dorchester Road) and crosses over CSX's Charleston Subdivision.

I-526 crosses over Norfolk Southern Railway's SC Line and has a partial cloverleaf interchange with Rivers Avenue, which carries US 52 and US 78.

[3] I-526 crosses the Cooper River on the high-level Don N. Holt Bridge and enters the Daniel Island section of the city of Charleston in Berkeley County.

The freeway has partial cloverleaf interchanges on either side of Beresford Creek with Clements Ferry Road and Seven Farms Drive/River Landing Drive.

I-526 continues southeast across the Wando River on the James B. Edwards Bridge back into Charleston County and the town of Mount Pleasant.

Some alternatives shown include the possibility that it will be built in expressway grade instead, falling short of being labeled an Interstate Highway.

[10] Citing Charleston County's inability to provide funds to cover the project's increased cost, the State Transportation Infrastructure Bank (SIB) board voted on May 26, 2016, to abandon the proposed extension of I-526 across James and Johns Islands.