Known as Admiral Taussig Boulevard, after US Navy Rear Admiral Edward D. Taussig, the Interstate runs 3.03 miles (4.88 km) from State Route 337 (SR 337) east to I-64 within the city of Norfolk.

I-564 begins within the reservation of Naval Station Norfolk where Admiral Taussig Boulevard becomes a four-lane freeway; this point is also the eastern terminus of SR 337.

I-564 curves southeast through a trumpet interchange with the access road to gates 3 and 3A.

[2][3] East of the tunnel, I-564 heads southeast parallel to a rail line between the naval air station to the north and Camp Allen, a US Marine Corps base, to the south.

Within the interchange, eastbound I-564 has an exit for westbound I-64 (Hampton Roads Beltway) and US 460 (Granby Street).