Interstate 64 (I-64) in the US state of Indiana is a major east–west highway providing access between Illinois and Kentucky.

It passes through southern Indiana as part of its connection between the two metropolitan areas of St Louis, Missouri, and Louisville, Kentucky.

Beyond the forest, the Interstate travels through Harrison and Floyd counties, before crossing the Sherman Minton Bridge over the Ohio River into Louisville, Kentucky.

[citation needed] Like all Interstate highways in Indiana, I-64 was constructed in segments which, when all were complete, made up the route in use today.

[citation needed] The Sherman Minton Bridge across the Ohio River was closed in 2011 after two major cracks were found.