Interstate 64 (I-64) in the US state of Kentucky travels for 191 miles (307 km), passing by the major towns and cities of Louisville, Frankfort, Lexington, and Ashland.

One is the Cochran Hill Tunnel,[2] a twin tube at Cherokee Park in Louisville built in 1974,[2] and the other is a 1960s-era modern-styled rest area near Winchester.

Moving eastward, I-64 passes through Shelbyville, Frankfort, Midway, Lexington, Winchester, Mount Sterling, Owingsville, and Morehead, before leaving the state near Ashland at Catlettsburg.

In March 2007, Governor Ernie Fletcher signed Senate Bill 83, which allowed for an increase in speed limits on rural Interstates and parkways.

[10] The section of highway featured three lanes of traffic in each direction on an elevated viaduct paralleling the Ohio River, carrying 90,000 vehicles per day.

The closure was part of a $50-million (equivalent to $70.8 million in 2023[8]) refurbishment project that involved replacing 132 expansion joints and repaving more than four miles (6.4 km) of Interstate and interchanges.

8664, a grassroots campaign with popular support but little apparent political momentum, aimed to reroute and remove I-64 to enhance Louisville's waterfront.