That stretch of road is the feeder route to the Keystone Shortway, a shortcut through northern Pennsylvania that provides access to New York City.

The two Interstates cross rural northwest Ohio and run just south of the Toledo metropolitan area.

In Elyria Township, Lorain County, just west of Cleveland, I-90 splits from I-80 (leaving the turnpike and running northeast as a freeway).

I-80 runs east-southeast through the southern suburbs of Cleveland and retains the Ohio Turnpike designation.

I-80 was constructed as part of the Ohio Turnpike (with the exception of modern I-76 and I-480), the origins of which predate the establishment of the Interstate Highway System in 1956.