The Interstate Highway, completed in 1966, spans 26 miles (42 km) through Berkeley County, paralleling U.S. Route 11 (US 11) for its entire length.

The first solicitations for the construction of I-81 were published in 1959, with the first six miles (9.7 km) of freeway being opened in 1963, and the full length was completed by 1966.

[3] The highway passes through some light farmland before entering a wooded area, north of Ridgeway.

A small business park is passed by before I-81 intersects County Route 32 (CR 32), providing access to Arden, Eastern WV Regional Airport, and Tablers Station.

[6] Every year, the West Virginia Department of Transportation (WVDOT) conducts a series of surveys on its highways in the state to measure traffic volume.

[10] A series of roads linking Virginia to Maryland through Martinsburg were present on maps as early as 1873.