For the most part, the 199-mile (320 km) drive is fairly benign, passing through the pine forests, farmlands, and blackwater streams and swamps of the Atlantic Plain.

[2] A flyover on twin high-spans over Lake Marion provides an unexpected scenic break in the center of the highway's length.

The South Carolina Department of Transportation (SCDOT) operates and maintains three welcome centers and five rest areas along I-95.

The location utilizes weigh-in-motion that does not require commercial motor vehicles to leave the freeway to be weighed.

I-95 in South Carolina feature numerous dedicated or memorialized bridges, interchanges, and stretches of freeway.

By 1967, more sections were under construction, including Pocotaligo to Walterboro and Santee to the North Carolina state line.

Also, discussions of possibly converting I-95 into a toll road were brought up but was met with resistance, especially within SCDOT.

[20] These tolls have been advocated by legislators in State Districts 36 and 40 in order to fund their counties (Clarendon and Orangeburg), where Lake Marion crosses.