Founded in Auckland, New Zealand by Dr. Mark Matthews and Dr. Andrew Hall in 1997, they have since moved their headquarters to the City of North Vancouver, British Columbia, Canada in 2005.

Intrahealth was founded in 1997 and spent its early years developing Profile and moving towards becoming one of New Zealand's largest vendors of Practice Management Systems (PMS).

The expansion saw additional contracts awarded from Vancouver Coastal, Interior, and Intertribal Health Authorities between that year and 2006.

[5] Profile for iOS was announced as a portable version of its practice management system in 2012, combining both a live online mode with syncing for offline use.

The selection followed a rigorous procurement process conducted by Velante, a subsidiary of the New Brunswick Medical Society, in which 16 other vendors submitted proposals.