Several spin-off series were released over its run: Brit, The Pact, Atom Eve & Rex Splode, and Guarding the Globe.

Initially the first three volumes focus on Mark as Invincible, who begins working as a superhero with his father acting as his mentor, and meeting other heroes (including Robot, Rex Splode, Dupli-Kate and Atom Eve).

His exploits range from discovering that his physics teacher has been turning his students into human bombs, to foiling a plan by the Mauler Twins to make an army of robots.

Meanwhile, Omni-Man kills the Guardians of the Globe in order to prepare Earth for the Viltrumite empire's impending invasion, leading Mark to battle his father.

Story arcs that follow this range from Mark traveling to alternate dimensions and battling villains like Angstrom Levy to facing off against Thragg, the emperor of the Viltrumite Empire, to determine the fate of Earth.

Kirkman has provided back-up space for a few aspiring comic creators, most notably Benito Cereno and Nate Bellegarde.

[7] In December 2024, it was announced that Kirkman and Ottley were developing a prequel spin-off series entitled Invincible Universe: Battle Beast.

[8] In 2003 and 2004, Image and Robert Kirkman published several other superhero series: Tech Jacket pencilled in a manga style by E. J. Su (cancelled at #6), the 3-issue Capes Inc. series drawn by Mark Englert and three oneshots starring Brit, the first two with artwork from Tony Moore and the third with artwork by Cliff Rathburn.

Tech Jacket was first collected as a digest-sized, black and white graphic novel and later reissued in regular sized, full color and a cover scheme similar to Kirkman's other trade paper backs.

[179] In January 2021, Kirkman reaffirmed that the film is still in development despite the release of a streaming television adaptation, and that Rogen and Goldberg are still involved with the project.