In August 2015, he was appointed Alternate Minister for Immigration Policy in the Caretaker Cabinet of Vassiliki Thanou-Christophilou.

[1] Mouzalas was appointed as the Alternate Minister of Immigration Policy in the Caretaker Cabinet of Vassiliki Thanou-Christophilou.

On 4 September, he announced four measures to help combat the European migrant crisis: creation of a coordination centre to manage the refugee flow, improved and increased logistical and staff support to existing facilities, taking immediate advantage of European solidarity program and community funds and providing necessary funds and resources to help local economies on the islands affected.

Following a lunchtime meeting with Alexis Tsipras, Kammenos declared that the "Independent Greeks support the government but not the migration minister."

Nevertheless, the government defended Mouzalas, saying in a statement that it was "irresponsible and hypocritical" to undermine him during the European migrant crisis.