The Ministry of the Interior (Greek: Υπουργείο Εσωτερικών) is a government department of Greece.

On 15 September 1995, it was merged with the Ministry of the Prime Minister's Office (Υπουργείο Προεδρίας της Κυβέρνησης) to form the Ministry of the Interior, Public Administration and Decentralization (Υπουργείο Εσωτερικών, Δημόσιας Διοίκησης και Αποκέντρωσης).

On 19 September 2007, it was merged with the Ministry of Public Order and reverted to its original name.

The merger was reversed on 7 October 2009, when the Ministry of the Interior, Decentralization and Electronic Governance (Υπουργείο Εσωτερικών, Αποκέντρωσης και Ηλεκτρονικής Διακυβέρνησης) was formed.

On 27 January 2015, the two were merged with the Ministry of Public Order and Citizen Protection to form the Ministry of the Interior and Administrative Reorganization (Υπουργείο Εσωτερικών και Διοικητικής Ανασυγκρότησης).