[4] Pallikaris became the director of the Department of Ophthalmology at the University of Crete, where he began focusing again on refractive surgery.
[3][5] Pallikaris serves as the Medical Advisory Board Chair for Presbia, an ophthalmic device company, where he is responsible for overseeing the post-market surveillance trials of the Flexivue Microlens, a corneal inlay treatment for presbyopia, the age-related loss of near vision.
[6][7] The Flexivue Microlens is a 3-mm in diameter lens that is inserted into a corneal pocket created by a femtosecond laser in the non-dominant eye of a presbyopic patient.
[3] Pallikaris' most significant impact has been in refractive surgery, with his most notable contribution being the development of LASIK, which he first performed on a human eye in 1990.
[12] Pallikaris has published more than 200 articles in international journals and holds over 20 patents related to optics and ophthalmology.