Iotapa (born c. 20 BC) was a daughter of King Mithridates III of Commagene.
She reigned as Queen of Commagene after marrying her King brother Antiochus III.
Iotapa was most probably born, raised and educated in Samosata, the capital of the Kingdom of Commagene.
Through her marriage to her brother, she had two children: a son, prince Antiochus IV of Commagene and a daughter, princess Iotapa.
The decision that Tiberius made was welcomed by many citizens by Commagene, but some, particularly those who were supporters of the royal family, were unhappy with this outcome.