Iowa 333 begins at exit 1 along I-29, approximately two miles (3.2 km) north of the Missouri state line.

The straightened route still ended at US 71, but now only one mile (1.6 km) north of Braddyville and the Missouri state line.

[7] For four days in December 1980, Iowa 333 consisted of only one mile (1.6 km) of road in Fremont County.

The committee identified over 700 miles (1,100 km) of state highways, including a significant portion of Iowa 333, which could be turned over to local jurisdictions.

[9] Most of the committee's recommendations were accepted and on July 1, 2003, and over 600 miles (970 km) of state highways were turned over to the counties or local jurisdictions.