North of Hamburg, it intersects Iowa 2, and the two routes share 5 miles (8.0 km) of road.

For 13 miles (21 km), US 275 overlaps I-29, ending at an interchange with Iowa 92 in southern Council Bluffs.

It crosses the Elkhorn River, which it will follow for most of the rest of the route, then separates from NE 92.

Before November 2001, US 275 ran alongside the Union Pacific tracks between Waterloo and Fremont, Nebraska.

This segment is officially called Reichmuth Road in Douglas County and Bell Street in Fremont.

Prior to July 1, 2003, US 275 followed a winding two-lane road between Council Bluffs and Glenwood, Iowa.

The segment moved to a concurrency with U.S. Route 34 and Interstate 29 that day as part of a mass decommissioning of highways in Iowa.

The route provided a direct connection from US 6 west of Omaha to US 275 south of Fremont.