At the consistory of April 1621, Gregory XV named him a cardinal with the title cardinal-deacon of S. Maria Nuova; in 1626 he opted for S. Angelo in Pescheria; and Sant'Eustachio in 1634.
[3] Ippolito was a patron of the arts in his own right, and employed the Baroque composer Domenico Mazzocchi, who entered his service in 1621.
[5] With her death in 1637, it passed to her eldest surviving son, Cardinal Ippolito, including the Villa Aldobrandini on the Quirinal.
[6] When the cardinal died the following year, the estate went to his niece, Olimpia Aldobrandini, the sole heiress to the family fortune.
Cardinal Aldobrandini died at the age of 42, on July 19, 1638, and was interred at Santa Maria sopra Minerva.