[3] In 1827, he went to Paris for a year in order to improve his knowledge of the method of decipherment proposed by Champollion.

A year later, Rosellini accompanied Champollion in the latter's Egyptian exploration also known as the Franco-Tuscan expedition, as the leader of the Tuscan group (1828–29).

Champollion's sudden death in 1832 left to the saddened Rosellini the whole responsibility of publishing the report of the expedition: between 1832 and 1843 he exposed the results in his most famous work, I Monumenti dell'Egitto e della Nubia, composed of three parts and nine volumes for a total of 3,300 text pages and 395 illustrated plates.

[2] Since 1836, Rosellini's health started to decline possibly due to malaria, which ultimately led to his death on 4 June 1843 in Pisa.

[2] Three years after his death, his widow married his brother Ferdinando Pio, a mathematician, who adopted their three sons.