[3] Early in Wicker's radio career, she changed the spelling of her first name to Ireene, adding the extra "e" as she was told by a numerologist that one more letter would bring her great success.

Although Wicker denied she had even heard of the man,[3] her listing within Red Channels was followed – in what she herself described as a "curious coincidence" – by her sponsor, Kellogg, failing to renew her option for the ABC TV show.

Among the stories produced were "Puss in Boots", "King Midas and the Golden Touch", "Little Red Riding Hood", and "Pinocchio".

One episode ("The Green Monkey") of The Ireene Wicker Show and 15 kinescopes of it are housed at the Library of Congress in the J. Fred and Leslie W. MacDonald Collection.

Wicker married Walter Charles Wicker, a radio writer, producer, and actor; they had a son, Walter Charles Jr.,[3] who during World War II joined one of the Eagle Squadrons that served with the RAF and was killed in action over the English Channel,[10] and a daughter, Nancy.