The earliest hospital at Fort Knox Kentucky, was a World War I cantonment building, constructed in 1918 on the site of the Lindsey Golf Course.

When the facility burned in 1928, medical services moved to the World War I guesthouse on Bullion Boulevard until a brick hospital was built in 1934 on E Street.

In 1940, two mobilization hospitals were constructed along Dixie Street, and were used until the multi-storied concrete structure opened in 1957.

A replacement clinic (Ireland Army Health Center) opened nearby 21 January 2020.

The hospital closed in 2020, with services moving to the adjacent Ireland Army Health Center (IRAHC), which opened 21 January 2020.