Irene is a city in Clay, Turner, and Yankton counties in South Dakota, United States.

[6] The portion of Irene that is located in Turner County is a part of the Sioux Falls, South Dakota metropolitan area, the portion located in Yankton County is part of the Yankton Micropolitan Statistical Area, and the portion located in Clay County is part of both the Vermillion Micropolitan Statistical Area and the Sioux City-Vermillion Combined Statistical Area.

[7] According to the United States Census Bureau, the city has a total area of 0.26 square miles (0.67 km2), all land.

There were 194 housing units at an average density of 746.2 per square mile (288.1/km2).

35.5% of all households were made up of individuals, and 15.7% had someone living alone who was 65 years of age or older.

32.5% of all households were made up of individuals, and 19.5% had someone living alone who was 65 years of age or older.