Irene Patricia Murphy Keeley (born January 17, 1944) is an inactive senior United States district judge of the United States District Court for the Northern District of West Virginia.

She received a Bachelor of Arts degree from College of Notre Dame of Maryland in 1965, a Master of Arts from West Virginia University in 1977, and a Juris Doctor from West Virginia University College of Law in 1980.

She was in private practice in Clarksburg, West Virginia from 1980 to 1992, and was an adjunct professor of law at the West Virginia University College of Law from 1990 to 1991.

[1] On April 1, 1992, Keeley was nominated by President George H. W. Bush to a new seat on the United States District Court for the Northern District of West Virginia created by 104 Stat.

She assumed senior status on August 12, 2017,[1] and inactive senior status on September 30, 2022.