[5] Where previously the College was in total control of its President Sedgrave, Talbot, and Eustace, from 1677 the College became more under the control of the diocese under the brief tenure of Bishop of Antwerp Aubertus van den Eede, this was in line with the Council of Trent decrees.
It was following James Clears appointment as president, and the episcopacy of Joannes Ferdinandus Van Beughem as Bishop of Antwerp, in 1679, that the first formal set of rules and regulations were agreed and printed.
[6] The Franciscan Bishop Leighlin Francisco de Ribera resided in the Irish College Antwerp, when he could not stay in Ireland.
James Talbot succeeded him as Rector/President in 1633, Talbot was followed by Nicholas Eustace (1642–1677), other Rectors/Presidents include James Cleer (1677–), John Egan, Martin Caddan, Peter Hennessy, Michael Hennessy (1704–1730), John Kent (1731–1732), Daniel O'Reilly (1732–1747), Hugh MacMahon(1747–1772 & 1774–1787), James MacMahon (1772–1774), and Hugh O'Reilly (1787–1795).
Bishop Peter Talbot (1620–1680), archbishop of Dublin (1671–1680), served as chair of theology in Antwerp.