[5] Following the matches in the United States, the Ireland team then toured the West Indies for a three-match ODI series.

[12] On 28 December 2021, the remaining ODI matches were each moved back by one day after a number of positive COVID-19 tests in the traveling parties,[13] before the series was ultimately cancelled.

[14] The curtailment of the series resulted in financial losses for USA Cricket, contributing to its year-end debt load.

[23] Ahead of Ireland's departure to the United States, Craig Young was identified as close contact of someone with a positive COVID-19 case.

[28] They were replaced by Ritwik Behera, Yasir Mohammad, Ali Sheikh, and Ryan Scott in their T20I squad,[29] and Kyle Phillip withdrew due to work commitments.