The character made her live-action debut in the Marvel Cinematic Universe film Black Widow, portrayed by Rachel Weisz.

Iron Maiden first appeared in Marvel Fanfare #11 (November 1983), created by Ralph Macchio and George Pérez.

[3] Feeling she was living in the shadow of Natalia Romanova / Black Widow, Iron Maiden started to develop a deep hatred for her.

[12] She then joined the Femizons, a team of superhuman female criminals led by Superia, whose purpose was to gain power and sterilize the planet in order to create a new world where women would rule.

Iron Maiden is a scientist who works on a project initiated by Reed Richards, which is meant to power the world using vibranium, in order to create an efficient energy source which would have no limit.

[35][36] In the New Exiles series, an unidentified female uses the Iron Maiden alias while using her own battlesuit and is a member of "Bloodforce" alongside Blackdog, Bloodwitch, Rough Justice, and Sandstorm.

[38][39] Melina Vostokoff appears in media set in the Marvel Cinematic Universe (MCU), portrayed by Rachel Weisz.