[5][6][7] Since her original introduction in comics, the character has been featured in various other Marvel-licensed products, including video games, animated television series, and merchandise.

A version of the character, Aida "Ophelia" / Madame Hydra, appears in the Marvel Cinematic Universe television series Agents of S.H.I.E.L.D.

[23] As the second Viper, she kidnapped Roxxon president Hugh Jones, in order to put the latter in thrall of the Serpent Crown.

[24] Viper was the founder and leader of the elite criminal underworld through sheer ruthlessness, treachery, and the cunning of her black heart.

She employed Boomerang and the Silver Samurai as operatives, and battled Spider-Man, Black Widow, Shang-Chi, and Nick Fury.

[25] Viper later employed the Silver Samurai as her chief operative, and attempted to kidnap Michael Kramer, a man carrying a fatal experimental disease, in order to release on America.

[26] Viper, employing Constrictor as her chief operative, captured Spider-Woman, believing she was responsible for making her think they were related.

It was revealed that Chthon had actually granted Viper false memories of mothering Jessica Drew as part of a plan to place both women under his control.

Re-employing the Silver Samurai, Viper attempted to coerce Team America into stealing the Cavourite Crystal, and then battled the New Mutants.

[28] In one of her many terrorist acts, she would try to gain control of the snake-themed organization called the Serpent Society, with Slither, Copperhead, Puff Adder, Fer-De-Lance, and Black Racer as her operatives.

Viper dispatched Cobra, Boomslang, and Copperhead to poison Washington D.C.'s water supply with a snake mutagen.

[42] Viper was then a member of an incarnation of the Hellfire Club, working with Courtney Ross, briefly under the title "White Warrior Princess".

[44] During the Dark Reign storyline, Viper is seen leaving her lover, the Silver Samurai, to rejoin Baron von Strucker and the ruling council of HYDRA.

[53] During the "Secret Empire" storyline, Viper attends the meeting of the HYDRA High Council and talks about the opening of two new detention facilities to double the amount of Inhumans held in indefinite custody.

[55] During the "Hunt for Wolverine" storyline, Viper is seen in Madripoor where she leads the Femme Fatales (consisting of Knockout, Bloodlust, Mindblast, Snake Whip, and Sapphire Styx) into ambushing Kitty Pryde, Domino, Jubilee, Psylocke, and Storm at the King's Impresario Restaurant.

While Psylocke, Rogue, and Storm are defeated and taken prisoner by Madame Hydra and the Femme Fatales, Pryde escapes with Domino and Jubilee.

As Viper gives the status report to a representative of her client, she mentions that Sapphire Styx is still draining off of Psylocke just like she did with Magneto.

As Snake Whip asks if they are going to ignore Sapphire Styx's vampiric appetite, Viper says that they have to obey the representative's orders and "let the @#$%& feed.

[60] Ophelia Sarkissian's strength, speed, reflexes, agility, dexterity, coordination, balance and endurance are on the order of an Olympic athlete.

She is a great swordsman and even greater marksman with most long range weapons, and has extensive training in hand-to-hand combat.

[61] She utilizes experimental weaponry, including a ring that enables teleportation, and in X-Treme X-Men, she made use of razor-sharp claw attachments apparently built into her gloves.

Perhaps her greatest strengths are her influence, the financial resources at her disposal due to her stature in organized crime, and an uncanny luck which has allowed her to cheat death in situations where lesser people would have died.

Kai Young of Screen Rant called Ophelia Sarkissian "one of the most recognizable villains in the Marvel Universe.

"[62] Marc Buxton of Den of Geek included Ophelia Sarkissian in their "Greatest Wolverine Villains" list.

[volume & issue needed] An alternate universe variant of Madame Hydra from Earth-1720, Susan Storm, appears in Exiles.

[78][79] Due to rights issues with Marvel Studios at the time, this version is not referred to as "Madame Hydra" nor is her affiliation with the organization referenced.

Ichiro Yashida hires Viper to help transfer Logan's healing factor to the former as well as monitor Kenuichio Harada's ninja clan.