Isa Khel is a sub-tribe of the Pashtun tribe, Niazi.

The earliest recorded mention of the Isa Khel tribe is in Baburnama, 1504-1505.

[1] Most of the tribe still resides in their ancestral town of Isakhel, named after their ancestor Isa Khan Niazi son of Umar Khan Niazi, but a lot have shifted to bigger cities or different towns in pursuit of a better education and livelihood opportunities.

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