The co-operative, opening in February 1866, was initially a great success, employing over 300 black workers.

[1] Myers and others also established the Colored Caulkers Trade Union Society in 1868, to which he was elected president.

The move was significant for what had previously been an all-white union, but black workers continued to face opposition to membership.

In response the Colored National Labor Union was established in 1869, with Myers as president.

[4][8] Following his departure from the CFNL Myers continued working and contributing to the labor movement.

He was the first known African American postal inspector, serving from 1870 until 1879, after which he returned to operate a coal yard in Baltimore.