Okoro played basketball for McEachern High School in Georgia for four years, helping his team win the state championship and achieve national success in his senior season.

In his freshman season, he averaged 15 points and eight rebounds per game, helping his team win the regional title and reach the Georgia High School Association Class 7A state quarterfinals.

[5][6] As a sophomore, Okoro averaged 22.5 points per game, leading McEachern to the regional championship and the Class 7A state semifinals.

[8][9] In his junior season, Okoro averaged 20.3 points and 6.4 rebounds per game, helping McEachern reach the Class 7A state quarterfinals.

[10][12] In the offseason, Okoro had success on the Nike Elite Youth Basketball League, a prominent amateur circuit, with Athletes of Tomorrow.

[18] He shared Atlanta Journal-Constitution state most valuable player recognition with teammate Sharife Cooper.

[25] Okoro became the second-highest-ranked commit in program history, according to 247Sports composite rankings, behind only Mustapha Heron.

On December 23, 2020, Okoro made his NBA debut, starting and recording 11 points, five assists, and three rebounds in a 121–114 win over the Charlotte Hornets.

[36] On March 23, 2023, Okoro had one rebound, one assist, and scored 11 points, including a game-winning three-pointer, in a 116–114 win over the Brooklyn Nets.

[38] Okoro played for the United States at the 2018 FIBA Under-17 Basketball World Cup in Argentina.