She became known in 1995, at age 13, following her role in the successful Telecinco series Médico de familia (Family Doctor) playing María, the eldest daughter of character Emilio Aragón, for five years.
After a period away from acting, Isabel Aboy signed on to Periodistas in 2001, where she played the scholar, Berta for the last two seasons of the production, also from Telecinco.
She was in Médico de familia (Family Doctor) in 2004 through the efforts of one of her colleagues, Luisa Martín (remembered from the Juani series).
In March 2007 a report appeared in the Telecinco's El Buscador program about child actors in which she spoke of her experience in Médico de familia.
In 2008 she opened in the play Al otro lado del tabique (Across the Wall) at the Teatro Lara in Madrid.