In between, she made one round trip to China for the British East India Company (EIC).

Under the command of Robert Berry and surgeon John Hallion, she left Spithead, England on 3 April 1818.

[5] On her second convict voyage under the command of John Wallis and surgeon William Price, she left Cork, Ireland on 4 November 1821, arrived in Sydney on 9 March 1822.

[6] An early outbreak of scurvy and a plot to cause a mutiny was put down during the voyage, and she arrived in Sydney on 16 December.

Homeward bound, she crossed the Second Bar on 10 February 1827, reached St Helena on 26 April, and arrived at The Downs on 3 June.

[1] On her fourth convict voyage under the command of William Wiseman and surgeon Thomas Galloway, she left Plymouth, England on 27 November 1831.

Her next convict voyage occurred under the command of David Brown and surgeon Oliver Sproule.

[15] Isabella's last convict voyage took place under the command of George Sinclair and surgeon Campbell France.