The Hudson's Bay Company (HBC) purchased her in 1829 and she was wrecked in 1830 on the Columbia River bar off Clatsop County, Oregon.

Lloyd's List reported in that Isabella, Cowle, master, had arrived at Omoa from Gibraltar.

The company purchased her to replace William and Ann, which had wrecked on the Columbia bar in May with the loss of all hands.

The HBC factor at Fort Vancouver sent Ryan and his men to salvage what of her cargo and stores they could.

[6] In 1986, researchers thought fisherman Daryl Hughes of Chinook had discovered the wreck of Isabella.