Isabella was a 323-ton merchant ship built in Whitby, England in 1827.

[3] Under the command of Alexander McAusland and surgeon Henry Mahon, Isabella left Dublin, Ireland, on 5 March 1840 and arrived at Sydney on 24 July 1840, having sailed via the Cape of Good Hope.

On 22 December, Isabella left Port Jackson bound for Guam in ballast.

[7] While sailing to Guam, Isabella was wrecked on a reef in the Caroline Islands on 30 January 1841.

The crew reached Manila safely after twenty-seven days in the boats.