The series started in 1966 and it was inspired in plot and title by the renowned novel Angélique, the Marquise of the Angels and its on-screen adaptation, which had had a significant success at the Italian box office.

Set in 17th century France, it features the adventures of Isabella de Frissac, an uninhibited noblewoman who works as a secret agent for cardinal Richelieu and, in the course if her missions, faces any sort of vexation and torture.

[1][2] The series is considered a progenitor of Italian adult comics, especially because of its sado-masochistic elements, which were an absolute innovation in the fumetti panorama.

The storylines also included grotesque situations, such as a scene in episode 8 which depicted the protagonist being raped by a bear.

[1] A film adaptation, Isabella, Duchess of the Devils, directed by Bruno Corbucci and starring Brigitte Skay in the title role, was released in 1969.