Isabella High School is a K-12 public school in the unincorporated community of Isabella, located in Maplesville, Chilton County, Alabama.

Education in the community of Isabella centered primarily around the Isabella Methodist Church for much of its early history.

[2] The school had included a vocational building for agricultural studies since 1923, the first agricultural department to be established within the county.

[2] In 1988, the school suffered a major fire which destroyed most of the original building.

By October 1989 a new set of buildings had been erected which the school currently occupies.